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The role of nicotinic acid in pathogenesis and therapy of psoriasis and eczema in patients abusing alcohol
AL Tischenko, SN Stetsyuk, LD Tishchenko,
IA Yusupov, FS Khalaf, SM TraoreI
[Article in Russian]
Bulletin of dermatology and venerology No.2 1998
Abstract
Fifty two patients with psoriasis (n=38) and eczema (n=14) abusing alcohol had significantly reduced blood nicotinic acid levels. Total nicotinic acid in these two groups of patients was only 270±3.2 and 385±12.8 mg% respectively compared with its normal value 620±4.6 mg%.
Free and albumin-bound nicotinic acid levels were 183±1.6 and 87±1.0 mg% respectively in psoriatic patients and 301±10.7 and 84±2.1 mg% in patients with eczema compared with 310±2.3 and 310±4.6 mg% respectively in healthy subjects (n=37). The heavy drinkers had the most severe forms of either disease characterized by extensive rash, strong itching, desquamation, and moist skin.
Therapy of these conditions encountered great difficulty. Preparations of
picamilone and vitamin B6 (pyridoxal phosphate) were used in combination with
piracetam to treat 28 patients with psoriasis, eczema, alcohol abuse.
Based on high therapeutic efficiency of these products bringing blood nicotinic acid levels to normal, they are recommended as choice agents for combined therapy of patients with psoriasis and eczema abusing alcohol.
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