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Spectrum of picamilone neuropharmacological
activity in animals under experiment
[Article in Russian]
Institute of Pharmacology,
B, Baltiyskaya st., Moscow, 125315, USSR
Abstract
During experiment in different animals it
has been revealed that picamilone with in the range of doses which don't evoke the depression of CNS has a pronounced anxiolytic effect and is free of myorelaxation typical to benzodiazepine related tranquilizers.
Picamilone was shown to recover working capacity following physical and psychic tiredness and improve reflectory activity disturbed by alcohol in addition to its stimulating and awakening effect in barbiturate narcosis and potentiation of opiate antinociceptive action.
There are reported the first results of pharmacological studies of picamilone
obtained in
neuro-pharmacological screening tests and LD50 in mice, under per os and i.p. administration of the drug.
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